On December 1, 2015, Wang, Gang; Wang, Yutao; Wang, Lei; Han, Leiqiang; Hou, Xuben; Fu, Huansheng; Fang, Hao published an article.Product Details of 97-09-6 The title of the article was Design, synthesis and preliminary bioactivity studies of imidazolidine-2,4-dione derivatives as Bcl-2 inhibitors. And the article contained the following:
Anti-apoptotic B-cell lymphoma-2 (Bcl-2) proteins are promising targets for cancer therapy. In the present study, a series of imidazolidine-2,4-dione derivatives were designed and synthesized to test their inhibitory activities against anti-apoptotic Bcl-2 proteins. Among them, compound 8k had better growth inhibitory effects on K562 and PC-3 cell lines compared to lead compound WL-276. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Product Details of 97-09-6
The Article related to imidazolidine dione derivative preparation bcl2 inhibitor antitumor leukemia, antitumor, bcl-2, imidazolidine-2,4-dione, inhibitors, Pharmacology: Structure-Activity and other aspects.Product Details of 97-09-6
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