On December 15, 2015, Wan, Yichao; Wang, Junhua; Sun, Feng-e; Chen, Minglu; Hou, Xuben; Fang, Hao published an article.Formula: C6H5ClN2O4S The title of the article was Design, synthesis and preliminary biological studies of pyrrolidine derivatives as Mcl-1 inhibitors. And the article contained the following:
Antiapoptotic proteins, such as B-cell lymphoma (Bcl-2) protein, myeloid cell leukemia sequence 1 (Mcl-1) protein, are potential targets for cancer treatment. In the studies, a series of pyrrolidine derivatives were developed as potent Mcl-1 inhibitors. The preliminary biol. studies suggested that most of target compounds exhibit good abilities for targeting Mcl-1 protein. Among them, compound I (Ki = 0.53 μM) exhibited equal inhibitory activities towards Mcl-1 protein compared to pos. control gossypol (Ki = 0.39 μM). This compound also possessed good antiproliferative activities against MDA-MB-231 and PC-3 cancer cells. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Formula: C6H5ClN2O4S
The Article related to preparation pyrrolidine antitumor neoplasm, anti-tumor, apoptosis, bcl-2, mcl-1, pyrrolidine, Pharmacology: Structure-Activity and other aspects.Formula: C6H5ClN2O4S
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics