Tinland, Bernard published an article in 1973, the title of the article was Theoretical EHT [extended Hueckel theory] study of structure-activity relations in a series of sulfonamides.Electric Literature of 97-09-6 And the article contains the following content:
The carbonic anhydrase inhibitory activities of 17 sulfonamides were compared with their structures, based on quantum chem. calculations performed within the framework of the extended Hueckel theory. Correlations were found between the activity of mols. and the reduced Mulliken overlap populations relative to the SO2 group. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Electric Literature of 97-09-6
The Article related to sulfonamide structure activity, quantum chem drug activity, carbonic anhydrase sulfonamide, Pharmacodynamics: Structure-Activity and other aspects.Electric Literature of 97-09-6
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics