Martinho, Nuno; Pires, Rita F.; Zloh, Mire; Bonifacio, Vasco D. B. published an article in 2021, the title of the article was Intrinsic acetamide brush-off by polyurea biodendrimers.Electric Literature of 685-91-6 And the article contains the following content:
The presence of genotoxic impurities in active pharmaceutical ingredients (APIs) is a major concern for the pharmaceutical industry. Acetamide is a common genotoxic byproduct found in synthetic routes of many APIs, mainly due to acetonitrile hydrolysis, and selective scavenging is a still a challenging task. Herein, as a proof-of-concept, we evaluate polyurea (PURE) biodendrimers as strategic nanopolymers to prepare safe drug nanoformulations from mixtures containing acetamide, using (S)-ibuprofen (IBF) as a model drug. Furthermore, computational mol. dynamics (MD) simulations were conducted to rationalize in vitro results and to identify the key intermol. interactions within mixtures Exptl. data were corroborated by MD simulations which showed that acetamide, IBF and carboxyfluorescein interactions with PURE biodendrimers are mostly at the surface. Also, PURE nanoformulations appear to be driven by hydrogen bonding, electrostatic and hydrophobic interactions. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Electric Literature of 685-91-6
The Article related to intrinsic acetamide nanoformulation polyurea biodendrimer, Pharmaceuticals: Pharmaceutics and other aspects.Electric Literature of 685-91-6
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics