On October 20, 2002, Li, Maojin; Hu, Junfeng; Li, Guozhen; Xie, Lin published an article.HPLC of Formula: 97-09-6 The title of the article was Antagonism of rhizoma gastrodiae to lead-induced damage of hippocampus in rats. And the article contained the following:
The antagonism of rhizoma gastrodiae (RGT) to the impairment of learning and memory ability induced by Lead was studied in rats. 36 Wistar rats were randomly divided into 3 groups, 12 rats in every group, (1) control group: treated with distilled water; lead group: treated with lead acetate(0.1 g/kg d); (3)lead-RGT group:lead acetate(0.1 g/kg d)+RGT(4.0 g/kg d). The ability of learning and memory of the rats was measured monthly by swimming test; 3 mo later, the rats were decapitated and nitric oxide(NO) and total antioxidative capacity(TAOC) in hippocampus were measured immediately and the examination for pathol. was also made. In swimming test, the number of seeking for anchorage in lead group(1, 2, 3 mo: 10.10±1.10, 7.80±1.32, 5.40±0.97 resp.) were significantly decreased, compared with the control(P < 0.01). The number of seeking for anchorage in RGT-lead group(1, 2, 3 mo: 11.90±0.95, 10.90±0.95, 9.7±0.96 resp.) were significantly increased, compared with lead group(P < 0.01). NO(0.733±0.015) μmol/g pro and TAOC(0.945±0.017) U/mg pro in hippocampus of lead group were significantly decreased compared with the control(P < 0.01) whereas NO(0.769±0.021) μmol/g pro and TAOC(0.986±0.010) U/mg pro in hippocampus of RGT-lead group were significantly increased compared with lead group(P < 0.01). Pathol. examination showed that in lead group, marked atrophy in hippocampus, cellular denaturation and necrosis, dissolution and disappearance in axon were found. In lead-RGT group, the atrophy of hippocampus was not obvious, the cell morphol. was nearly normal, no obvious abnormal changes were seen. RGT is antagnostic to the impairment of hippocampus and of learning and memory ability induced by lead. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).HPLC of Formula: 97-09-6
The Article related to lead gastrodia tianma hippocampus damage, Pharmaceuticals: Pharmacognostic Products and other aspects.HPLC of Formula: 97-09-6
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