On November 30, 2016, Guillon, Jean; Moreau, Stephane; Ronga, Luisa; Basmacyian, Louise; Cohen, Anita; Rubio, Sandra; Bentzinger, Guillaume; Savrimoutou, Solene; Azas, Nadine; Mullie, Catherine; Sonnet, Pascal published an article.HPLC of Formula: 5455-98-1 The title of the article was Design, Synthesis and Antimalarial Activity of Some New Aminoalcoholpyrrolo[1,2-a]quinoxaline Derivatives. And the article contained the following:
Following our search for antimalarial compounds, novel series of piperazinylalc. pyrrolo[ 1,2-a]quinoxaline derivatives 1-2 were synthesized from 2-nitroaniline or 2-amino-3- nitrophenol and tested for in vitro activity upon the intraerythrocytic stage of W2 and 3D7 Plasmodium falciparum strains. Biol. results showed good antimalarial activity with IC50 ranging from 0.3 to 21.1 μM. In attempting to investigate the large broad-spectrum antiprotozoal activities of these pyrrolo[1,2-a]quinoxaline derivatives, their properties toward the promastigote form of Leishmania donovani were also investigated and revealed their selective antiplasmodial profile. In parallel, the in vitro cytotoxicity of these mols. was assessed on the human HepG2 cell line. Structure-activity relationships of these new synthetic compounds are here discussed. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).HPLC of Formula: 5455-98-1
The Article related to antimalarial msbar, Pharmacology: Structure-Activity and other aspects.HPLC of Formula: 5455-98-1
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