On March 31, 1985, De Benedetti, Pier G.; Menziani, M. Cristina; Frassineti, Chiara published an article.Reference of 3-Nitro-4-chlorobenzenesulfonamide The title of the article was A quantum chemical QSAR study of carbonic anhydrase inhibition by sulfonamides. Sulfonamide carbonic anhydrase inhibitors: quantum chemical QSAR. And the article contained the following:
MO indexes were computed (CNDO/2) for 3 series of sulfonamide inhibitors, (in their neutral and anionic forms) of carbonic anhydrase [9001-03-0]. Linear regression analyses between the calculated indexes and both physico-chem. and enzyme inhibition data gave good correlations which allowed the testing of predictive and diagnostic aspects of the quant. structure-activity relationships employing quantum chem. indexes. Results indicated that the mol. size affects the inhibitory power among the different sulfonamide derivatives (aliphatic, arylic and bridged diarylic) but not significantly within each mol. series. Results indicated further that the MO indexes are good predictors of the various exptl. mol. properties and suggest that the less electron-rich the sulfamoyl group is, the more favored are both the hydrophobic and hydrophilic steps leading to enzyme inhibition. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Reference of 3-Nitro-4-chlorobenzenesulfonamide
The Article related to carbonic anhydrase inhibition sulfonamide qsar, qsar sulfonamide derivative, structure activity sulfonamide derivative, mo sulfonamide, Pharmacology: Structure-Activity and other aspects.Reference of 3-Nitro-4-chlorobenzenesulfonamide
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