On May 20, 2015, Wang, Zhen; Kuninobu, Yoichiro; Kanai, Motomu published an article.Computed Properties of 5455-98-1 The title of the article was Palladium-Catalyzed Oxirane-Opening Reaction with Arenes via C-H Bond Activation. And the article contained the following:
We achieved a palladium-catalyzed C-H activation/C-C coupling reaction between arenes with a pyridyl, aminoquinolinyl, imino, or amide directing group, and oxiranes. The reaction proceeded at room temperature without any additives and tolerated a wide variety of functional groups, and the products were obtained in good to excellent yields, even on gram scale. This is the first example of a transition-metal-catalyzed intermol. direct coupling reaction between a C-H bond of aromatic compounds and a carbon atom of oxiranes via C-H bond activation. By using N-methoxybenzamide as a substrate, we obtained 3-substituted isochroman-1-ones in one pot. The coupling reaction proceeded with stereoretention. Kinetic isotope effect experiments suggested that C-H bond activation is the rate-determining step. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Computed Properties of 5455-98-1
The Article related to arene oxirane ring opening palladium catalyst, carbon hydrogen bond activation intermol direct coupling, hydroxyalkyl arene preparation, General Organic Chemistry: Synthetic Methods and other aspects.Computed Properties of 5455-98-1
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics