On February 5, 2021, Wang, Xia; Yang, Peng; Hu, Bo; Zhang, Qian; Li, Dong published an article.SDS of cas: 102-07-8 The title of the article was Hypervalent Iodine Reagent-Promoted Hofmann-Type Rearrangement/Carboxylation of Primary Amides. And the article contained the following:
A novel transformation of primary amides RC(O)NH2 (R = Ph, thiophen-2-yl, Bu, cyclopropyl, etc.) to secondary amides RNHC(O)R1 (R1 = methyltrifluoromethyl, Et, Ph, etc.) promoted by hypervalent iodine reagents Ph(I)(OC(O)R1)2 was developed. The hypervalent iodine reagent-mediated Hofmann-type rearrangement generated an isocyanate intermediate, which was subsequently trapped by an in situ generated carboxylic acid from the hypervalent iodine reagent to provide the corresponding secondary amides. This method provided a facile and efficient route for the synthesis of secondary amides from primary amides and also revealed novel reactivities of hypervalent iodine reagents. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).SDS of cas: 102-07-8
The Article related to secondary amide preparation, primary amide hypervalent iodine reagent hofmann rearrangement carboxylation, General Organic Chemistry: Synthetic Methods and other aspects.SDS of cas: 102-07-8
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics