On June 5, 2020, Wang, Jiajia; Wen, Yinhang; Zheng, Lu; Dou, Biao; Li, Linrong; Zhao, Kangkang; Wang, Na; Ma, Jing published an article.SDS of cas: 102-07-8 The title of the article was Characterization of chemical profiles of pH-sensitive cleavable D-gluconhydroximo-1, 5-lactam hydrolysates by LC-MS: A potential agent for promoting tumor-targeted drug delivery. And the article contained the following:
Currently, controllable linker cleavage at the target site will facilitate the clin. treatment of cancer. Dual-functional prodrugs in combination of carbohydrate as targeting group and pH-sensitive cleavable linker are desired in clin. development. Here, a qualified structure of N-phenylcarbamate-D-gluconhydroximo-1,5-lactam was employed and proved to be a potential candidate prodrug in the drug design. To proof this concept, the possible mechanism of Beckmann rearrangement and the degraded products were confirmed by HPLC and LC-MS under the acid condition mimic lysosome. Hence, the strategy of D-gluconhydroximo-1,5-lactam as a prodrug carrier fabricated with interested drugs will provide a great potential approach for chemotherapy. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).SDS of cas: 102-07-8
The Article related to gluconhydroximolactam tumor targeting prodrug, beckmann rearrangement, n-phenylcarbamate-d-gluconhydroximo-1,5-lactam, prodrug, ph sensitive, Pharmaceuticals: Formulation and Compounding and other aspects.SDS of cas: 102-07-8
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