On October 1, 2021, Wang, Bin; Feng, Weiwei; Wang, Jinan; Dong, Yuanzhen; Liu, Yanlong; Yao, Yiyan; Zhang, Jianqing; Shi, Wei; Liu, Limin; Zhang, Hongying; He, Xiangyi; Chang, Xiayun; Wang, Xiaojin; Xu, Hongjiang; Liu, Fei; Feng, Jun published an article.Electric Literature of 97-09-6 The title of the article was Discovery of potent and selective Bcl-2 inhibitors with acyl sulfonamide skeleton. And the article contained the following:
The antiapoptotic protein B-cell lymphoma 2 (Bcl-2), overexpressed in many tumor cells, is an attractive target for potential small mol. anticancer drug discovery. Herein, a series of novel derivatives with acyl sulfonamide skeleton was designed, synthesized, and evaluated as Bcl-2 inhibitors by means of bioisosteric replacement. Among them, compound 24g demonstrated equal efficient inhibition activity against RS4;11 cell line compared to pos. control ABT-199. Moreover, it showed improved selectivity for Bcl-2/Bcl-xL inhibitory effects, the result of which was consistent with platelet toxicity studies. In vitro and in vivo pharmacokinetic properties of compound 24g had a significantly improved profiles. Taken together, those results suggested it as a promising candidate for development of novel therapeutics targeting Bcl-2 in cancer. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Electric Literature of 97-09-6
The Article related to acute lymphoblastic leukemia synthesis acyl sulfonamide bcl2 inhibitor design, acyl sulfonamide, apoptosis, bcl-2 inhibitors, metabolic stability, selectivity, Placeholder for records without volume info and other aspects.Electric Literature of 97-09-6
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