On May 20, 2015, Pant, Kritee; Groeger, Dominic; Bergmann, Ralf; Pietzsch, Jens; Steinbach, Joerg; Graham, Bim; Spiccia, Leone; Berthon, Fannely; Czarny, Bertrand; Devel, Laurent; Dive, Vincent; Stephan, Holger; Haag, Rainer published an article.Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was Synthesis and Biodistribution Studies of 3H- and 64Cu-Labeled Dendritic Polyglycerol and Dendritic Polyglycerol Sulfate. And the article contained the following:
Dendritic polyglycerol sulfate (dPGS) is a biocompatible, bioactive polymer which exhibits anti-inflammatory activity in vivo and thus represents a promising candidate for therapeutic and diagnostic applications. To investigate the in vivo pharmacokinetics in detail, dPGS with a mol. weight of approx. 10 kDa was radiolabeled with 3H and 64Cu, and evaluated by performing biodistribution studies and small animal positron emission tomog. (PET). 3H-labeling was accomplished by an oxidation-reduction process with sodium periodate and [3H]-borohydride. 64Cu-labeling was achieved by conjugation of isothiocyanate- or maleimide-functionalized copper(II)-chelating ligands based on 1,4-bis(2-pyridinylmethyl)-1,4,7-triazacyclononane (DMPTACN) to an amino functionalized dPGS scaffold, followed by reaction with an aqueous solution containing 64CuCl2. Independent biodistribution by radioimaging and PET imaging studies with healthy mice and rats showed that the neutral dPG was quant. renally eliminated, whereas the polysulfated analogs accumulated mainly in the liver and spleen. Small amounts of the dPGS derivatives were slowly excreted via the kidneys. The degree of uptake by the reticuloendothelial system (RES) was similar for dPGS with 40% or 85% sulfation, and surface modification of the scaffold with the DMPTACN chelator did not appear to significantly affect the biodistribution profile. On the basis of our data, the applicability of bioactive dPGS as a therapeutic agent might be limited due to organ accumulation even after 3 wk. The inert characteristics and clearance of the neutral polymer, however, emphasizes the potential of dPG as a multifunctional scaffold for various nanomedical applications. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione
The Article related to tritium copper 64 dendrimer polyglycerol sulfate chelator biodistribution preparation, Pharmaceuticals: Formulation and Compounding and other aspects.Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione
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