Li, Dan-Dan; Niu, Liang-Feng; Ju, Zhi-Yu; Xu, Zhihong; Wu, Changzeng published an article in 2016, the title of the article was Palladium-Catalyzed C(sp2)-H Bond Alkylation of Ketoximes by Using the Ring-Opening of Epoxides.Electric Literature of 5455-98-1 And the article contains the following content:
A palladium-catalyzed ortho-directed alkylation of O-Me ketoximes that proceeds through a regioselective ring-opening reaction of epoxides has been demonstrated. This C(sp2)-H activation/alkylation protocol was carried out in pivalic acid/1,1,1,3,3,3-hexafluoro-2-propanol (PivOH/HFIP, 2:8) as the solvent and was applied to various O-Me ketoximes that contain either electron-donating or electron-withdrawing groups. Moreover, different types of epoxides were used in this alkylation reaction, which proceeded smoothly to give the corresponding products in moderate to good yields. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Electric Literature of 5455-98-1
The Article related to regioselective palladium catalyst alkylation ketoxime ring opening epoxide, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 5455-98-1
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