On November 30, 2021, Han, Bo; Zhang, Jiong; Jiao, Haijun; Wu, Lipeng published an article.SDS of cas: 685-91-6 The title of the article was Zirconium-hydride-catalyzed site-selective hydroboration of amides for the synthesis of amines: Mechanism, scope, and application. And the article contained the following:
The selective hydroboration of primary, secondary, and tertiary amides at room temperature catalyzed by an earth-abundant-metal catalyst, Zr-H, for accessing diverse amines was reported. Various readily reducible functional groups, such as esters, alkynes, and alkenes, were well tolerated. Furthermore, the methodol. was extended to the synthesis of bio- and drug-derived amines. Detailed mechanistic studies revealed a reaction pathway entailing aldehyde and amido complex formation via an unusual C-N bond cleavage-reformation process, followed by C-O bond cleavage. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).SDS of cas: 685-91-6
The Article related to amide zirconium hydride catalyst regioselective hydroboration, amine preparation reaction mechanism, General Organic Chemistry: Synthetic Methods and other aspects.SDS of cas: 685-91-6
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics