Chhatwal, A. Rosie; Lomax, Helen V.; Blacker, A. John; Williams, Jonathan M. J.; Marce, Patricia published an article in 2020, the title of the article was Direct synthesis of amides from nonactivated carboxylic acids using urea as nitrogen source and Mg(NO3)2 or imidazole as catalysts.Recommanded Product: 1,3-Diphenylurea And the article contains the following content:
A new method for the direct synthesis of primary and secondary amides from carboxylic acids was described using Mg(NO3)2路6H2O or imidazole as a low-cost and readily available catalyst, and urea as a stable, and easy to manipulate nitrogen source. This methodol. was particularly useful for the direct synthesis of primary and Me amides avoiding the use of ammonia and methylamine gas which can be tedious to manipulate. Furthermore, the transformation does not require the employment of coupling or activating agents which are commonly required. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Recommanded Product: 1,3-Diphenylurea
The Article related to urea carboxylic acid magnesium nitrate imidazole catalyst coupling, primary amide preparation, secondary amide preparation, General Organic Chemistry: Synthetic Methods and other aspects.Recommanded Product: 1,3-Diphenylurea
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics