Chen, Changpeng; Ling, Liang; Luo, Meiming; Zeng, Xiaoming published an article in 2021, the title of the article was Chromium-Catalyzed Ligand-Free Amidation of Esters with Anilines.Reference of 1,3-Diphenylurea And the article contains the following content:
Amides are important structural motifs in pharmaceutical and agrochem. chem. because of the intriguing biol. active properties. Author’s report here the amidation of com. available esters with anilines that was promoted by low-cost and air-stable chromium(III) pre-catalyst combined with magnesium, providing access to amides. This reaction occurs without the use of external ligands in a simple operation. Mechanistic studies indicate that a reactive aminated Cr species responsible for the amidation can be considered, which may be formed by reaction of low-valent Cr with aniline followed by reduction with hydrogen evolution. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Reference of 1,3-Diphenylurea
The Article related to secondary amide tertiary preparation chromium catalyst, ester aniline amidation, General Organic Chemistry: Synthetic Methods and other aspects.Reference of 1,3-Diphenylurea
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics