Chatterjee, Puranjan; Wang, Hsin; Manzano, J. Sebastian; Kanbur, Uddhav; Sadow, Aaron D.; Slowing, Igor I. published an article in 2022, the title of the article was Surface ligands enhance the catalytic activity of supported Au nanoparticles for the aerobic 伪-oxidation of amines to amides.Name: N,N-Diethylacetamide And the article contains the following content:
The catalytic aerobic 伪-oxidation of amines in water is an atom economic and green alternative to current methods of amide synthesis. The reaction uses O2 as terminal oxidant, avoids hazardous reactants and gives water as the only byproduct. Here we report that the catalytic activity of silica-supported Au nanoparticles for the aerobic 伪-oxidation of amines can be improved by tethering pyridyl ligands to the support. In contrast, immobilization of thiol groups on the material gives activities comparable to Au supported on bare silica. Our studies indicate that the ligands affect the electronic properties of the Au nanoparticles and thereby determine their ability to activate O2 and mediate C-H cleavage in the amine substrate. The reaction likely proceeds via an Au catalyzed 尾-hydride elimination enabled by back donation from electron-rich metal to the orbital. O2, which is also activated on electron-rich Au, acts as a scavenger to remove H from the metal surface and regenerate the active sites. The mechanistic understanding of the catalytic conversion led to a new approach for forming C-C bonds 伪 to the N atoms of amines. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Name: N,N-Diethylacetamide
The Article related to amide preparation amine aerobic alpha oxidation, supported au nanoparticle catalysis, General Organic Chemistry: Synthetic Methods and other aspects.Name: N,N-Diethylacetamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics