Xue, Weifeng; Zhang, Haiqin; Wang, Mei; Liu, Ying; Liu, Mengyao; Shen, Baozhen published an article in 2022, the title of the article was Metabolomics-based non-targeted screening analysis of 34 PPCPs in bovine and piscine muscles.Application of 144-80-9 And the article contains the following content:
The metabolomics-based anal. strategy has showed superiority on the non-targeted screening of contaminants, especially for unknown and unexpected (U&U) contaminants in the field of food safety, but data anal. is often the bottleneck of the strategy. In this study, a novel metabolomics-based anal. method via searching for marker compounds was developed on the basis of ultrahigh-performance liquid chromatog.-tandem mass spectrometry (UHPLC-MS/MS) results to accurately, rapidly and comprehensively achieve the non-targeted screening of 34 pharmaceutical and personal care products (PPCPs) as U&U contaminants spiked in bovine and piscine muscle matrixes. Three concentration groups (20, 50 and 100 ng mL-1) were intentionally designed to simulate the control and exptl. groups for the discovery of marker compounds, for which multivariate and univariate analyses were adopted. In multivariate anal., each concentration group was fully separated from the other two groups in PCA and OPLS-DA plots, laying a foundation to distinguish marker compounds among groups. The S-plot, permutation and variable importance in projection (VIP) in OPLS-DA were employed to screen and identify marker compounds, which were further verified by pairwise t-test and fold change judgement in univariate anal. The results indicate that 34 PPCPs spiked in two muscle matrixes were all identified as marker compounds, proving the validity and practicability of this novel metabolomics-based non-targeted screening method, which will exhibit great superiority and broad application prospects, especially in the face of massive PPCPs and various animal matrixes in the field of food safety control. In addition, the limits of detection (LODs) for 34 PPCPs were calculated to be 0.2-2.6μg kg-1 and 0.3-2.1μg kg-1 in bovine and piscine muscle matrixes, resp. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Application of 144-80-9
The Article related to muscle pharmaceutical personal care product metabolomics screening, Biochemical Methods: Spectral and Related Methods and other aspects.Application of 144-80-9
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