On April 15, 2022, Xu, Liang; Liu, Yan; Meng, Faming; Lu, Hanbin; Li, Youzhi published a patent.Reference of (S)-2-Hydroxy-N-methyl-2-phenylacetamide The title of the patent was Preparation of 3,5-diamide-1,4-dihydropyridine hydrogenation reagent and its application. And the patent contained the following:
The invention discloses a preparation of 3,5-diamide-1,4-dihydropyridine hydrogenation reagent and its application, which has the advantages of simple synthesis method, mild reaction conditions, and can effectively reduce the production cost and improve the production safety. The hydrogenation reagent is shown in formula I, wherein R is selected from hydrogen atom, linear alkyl with 1-20 carbon atoms, branched alkyl with 3-10 carbon atoms and branched alkyl with 3-10 carbon atoms-cycloalkyl group with 10 carbon atoms, or substituted or unsubstituted Ph group. The hydrogenation reagent was prepared via ring opening reaction and heterocyclization. The step of asym. hydrogenation includes the following steps: mixing the substrate, the hydrogenation reagent, proton acid and organic solvent, separating and purifying after the reaction is complete. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Reference of (S)-2-Hydroxy-N-methyl-2-phenylacetamide
The Article related to preparation diamide dihydropyridine hydrogenation reagent ring opening reaction heterocyclization, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Reference of (S)-2-Hydroxy-N-methyl-2-phenylacetamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics