On July 25, 2007, Yu, Xuhui; Ge, Hongyan; Zhang, Lei; Song, Han; Yu, Ying; Wang, Yuhong published an article.Synthetic Route of 456-12-2 The title of the article was Expressions of IL-12 and IL-18 in patients with acute optic neuritis before and after methylprednisolone pulse therapy. And the article contained the following:
The expressions of interleukin-12 (IL-12) and interleukin-18 (IL-18) and the relationship between IL-12 and IL-18 in acute optic neuritis (AON) before and after methylprednisolone pulse therapy (MPPT) were investigated. ELISA was employed to determine the expressions of IL-12 and IL-18 in serum in 27 patients with AON before and after MPPT. RT-PCR anal. was employed to demonstrate the expressions of IL-12 and IL-18 receptors in peripheral lymphocytes. The serum level of IL-12 was decreased from (45.6±12.2) ng/L to (17.1±4.7) ng/L after MPPT (P < 0.01), and that of IL-18 was decreased from (157.5±39.3) ng/L to (126.2±22.6) ng/L (P < 0.05). The expression of IL12R mRNA was decreased after MPPT too (0.2948 vs. 0.1507, P < 0.05), and so was that of IL18R mRNA (0.5352 vs. 0.2843, P < 0.05). The expressions of IL-12 and IL-18 as well as those of their receptors were pos. correlated. Methylprednisolone could exert its important antiphlogistic action against AON by inhibiting the expressions of the proinflammatory cytokines, IL-2 and IL-18. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Synthetic Route of 456-12-2
The Article related to interleukin il12 il18 optic neuritis methylprednisolone antiinflammatory, Mammalian Hormones: Corticosteroid, Gonadal, and Placental Hormones and other aspects.Synthetic Route of 456-12-2
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