On November 22, 2019, Sulake, Rohidas Shivaji; Mitra, Rangan; Kadam, Navnath Ambadas; Siyan, Rajinder Singh; Bhise, Nandu Baban; Singh, Girij Pal published a patent.HPLC of Formula: 5455-98-1 The title of the patent was Process for preparation of Neratinib intermediates. And the patent contained the following:
The present invention relates to a process for the preparation of Neratinib intermediates of compound I and compound II [X = halo]. The process involves reaction of compound III [LG = a leaving group] with acetonitrile to yield compound IV [LG is as defined above], reaction of IV with dimethylacetamide to yield compound V [LG is as defined above]; cyclizing V to yield compound VI; halogenation of VI to yield compound VII [X = halo] and reduction of VII to yield II [X = halo]; optionally II can be protected to yield compound VIII [X = halo]. E.g., a multi-step synthesis of VIII [X = Cl], starting from III [LG = OEt] (preparation given) and acetonitrile, was described. The process for the preparation of compound I which comprises the steps of: (a) reacting compound IX [R = alkyl] with alkyl acetate to give compound X [R = alkyl], (b) reducing X 7 in the presence of reducing agent to obtain a compound XI [R = alkyl], and (c) converting XI to compound I, was disclosed. For example, reacting IX [R = Et] with tert-Bu acetate followed by reducing X [R = Et] using NaBH4, and treating XI [R = Et] with Et3N, MsCl in DCM, and hydrolysis of resulting tert-Bu (E)-4-(dimethylamino)but-2-enoate in EtOAc-HCl solution afforded I.HCl. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).HPLC of Formula: 5455-98-1
The Article related to neratinib intermediate preparation, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.HPLC of Formula: 5455-98-1
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics