On July 31, 2011, Nugroho, Agung Endro; Riyanto, Sugeng; Sukari, Mohamad Aspollah; Maeyama, Kazutaka published an article.Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the article was Effects of aegeline, a main alkaloid of Aegle marmelos correa leaves, on the histamine release from mast cells. And the article contained the following:
Aegeline or N-[2-hydroxy-2(4-methoxyphenyl) ethyl]-3-phenyl-2-propenamide is a main alkaloid isolated from Aegle marmelos Correa collected in Yogyakarta Indonesia. In our study, we investigated the effects of aegeline on the histamine release from mast cell. The study was performed by using (1) rat basophilic leukemia (RBL-2H3) cell line, and (2) rat peritoneal mast cells (RPMCs). DNP24-BSA, thapsigargin, ionomycin, compound 48/80 and PMA were used as inducers for histamine release from mast cell. In our study, aegeline inhibited the histamine release from RBL-2H3 cells induced by DNP24-BSA. Indeed, aegeline showed strong inhibition when RBL-2H3 cells induced by Ca2+ stimulants such as thapsigargin and ionomycin. Aegeline is suggested to influence the intracellular Ca2+ pool only since could not inhibit the 45Ca2+ influx into RBL-2H3 cells. Aegeline showed weak inhibitory effects on the histamine release from RPMCs, even though still succeed to inhibit when the histamine release induced by thapsigargin. These findings indicate that aegeline altered the signaling pathway related to the intracellular Ca2+ pool in which thapsigargin acts. Based on the results, the inhibitory effects of aegeline on the histamine release from mast cells depended on the type of mast cell and also involved some mechanisms related to intracellular Ca2+ signaling events via the same target of the action of thapsigargin or downstream process of intracellular Ca2+ signaling in mast cells. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide
The Article related to antihistamine aegeline alkaloid aegle leaf histamine release mast cell, Pharmacology: Effects Of Gastrointestinal and Respiratory Drugs and other aspects.Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics