On May 11, 2018, Zhang, Xiaoqing; Song, Zhichun; Bao, Jinyuan published a patent.Application of 16230-24-3 The title of the patent was Preparation of pyrimidine derivatives useful as IDO inhibitors. And the patent contained the following:
The invention relates to pyrimidine derivatives of formula I, and their pharmaceutically acceptable salts, isomers, racemates, diastereoisomers and pharmaceutical composition thereof, method for their preparation and their use for the treatment of diseases related to indoleamine 2,3-dioxygenase (IDO), specifically in the treatment of tumors, Alzheimer’s disease, depression, cataract, etc. Compounds of formula I, wherein R2 is halo, H, (un)substituted Ph, 4-pyrazolyl, etc.; R is (un)substituted C5-12aryl, C1-6alkyl, NH2, 1-substituted-4-pyrazolyl, etc.; W is 4-fluoroanilino, C1-6alkoxy, cyclopentylamino, 4- to 8-membered heterocycle containing at least one N, and their pharmaceutically acceptable salts, are claimed. Example compound II was prepared via a multistep procedure (procedure given). All the invention compounds were evaluated for their IDO inhibitory activity. From the assay, it was determined that example compound II exhibited 46 % and 26 % inhibition towards IDO1 at 10 μM and 1 μM resp. Pharmacokinetic behaviors of the invented compounds in rats are studied, and the results show that the compound of the present invention has a significant pharmacokinetic absorption effect and a good clin. application prospect. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Application of 16230-24-3
The Article related to pyrimidine derivative preparation ido inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application of 16230-24-3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics