On January 1, 2018, Satish, Sabbu; Srivastava, Ankita; Yadav, Pragya; Varshney, Salil; Choudhary, Rakhi; Balaramnavar, Vishal M.; Narender, Tadigoppula; Gaikwad, Anil Nilkanth published an article.Related Products of 456-12-2 The title of the article was Aegeline inspired synthesis of novel amino alcohol and thiazolidinedione hybrids with antiadipogenic activity in 3T3-L1 cells. And the article contained the following:
Excess adiposity is a hallmark of obesity, which is caused due to an imbalance between energy intake and energy consumed. Obesity is often associated with several metabolic disorders like dyslipidemia, cardiovascular diseases and type 2 diabetes. Earlier, the authors’ group had reported natural product Aegeline (amino-alc.) isolated from the plant Aegle marmelos as an anti-diabetic and anti-dyslipidemic compound With this background, the authors synthesized a series of novel amino alc. and thiazolidinedione hybrid mols. and studied their antiadipogenic activity. As a result, the authors have identified a potent hybrid compound (Z)-3-benzyl-5-(4-(3-(3,4-dichlorobenzylamino)-2-hydroxypropoxy)benzylidene)thiazolidine-2,4-dione as an inhibitor of adipocyte differentiation. The compound (Z)-3-benzyl-5-(4-(3-(3,4-dichlorobenzylamino)-2-hydroxypropoxy)benzylidene)thiazolidine-2,4-dione inhibits lipid accumulation and adipogenesis in 3T3-L1 preadipocyte cell line. Exposure of compound (Z)-3-benzyl-5-(4-(3-(3,4-dichlorobenzylamino)-2-hydroxypropoxy)benzylidene)thiazolidine-2,4-dione blocks mitotic clonal expansion and arrests cells in S-phase of cell cycle. Detailed anal. showed that compound (Z)-3-benzyl-5-(4-(3-(3,4-dichlorobenzylamino)-2-hydroxypropoxy)benzylidene)thiazolidine-2,4-dione decreases expression of two major transcription factors that are involved in adipocyte differentiation, PPARγ, C/EBPα, and other adipogenesis associated genes like aP2 and FAS. Thus, compound (Z)-3-benzyl-5-(4-(3-(3,4-dichlorobenzylamino)-2-hydroxypropoxy)benzylidene)thiazolidine-2,4-dione shows potential ability to inhibit adipocyte differentiation which can be used therapeutically for the treatment of obesity and its associated metabolic disorders. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Related Products of 456-12-2
The Article related to alc thiazolidinedione hybrid preparation antiadipogenic agent, adipogenesis, obesity, pparγ, thiazolidinedione, β-amino alcohols, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 456-12-2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics