On December 29, 2020, Li, Yanxiong; Xu, Liang; Meng, Faming; Yu, Yonghai published a patent.Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide The title of the patent was Method for synthesizing (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline using 1-phenyl-3,4-dihydroisoquinoline. And the patent contained the following:
The present invention relates to a (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline synthesizing method comprising: mixing 1-phenyl-3,4-dihydroisoquinoline, chiral catalyst, acid and solvent, and reacting them. The (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline with high chiral purity can be generated during the hydrogenation reduction process. The product is easy to sep. and purify, and the yield is high. In addition, the reaction conditions are mild, the process is stable, the reaction operation is simple, convenient and safe, the production cost is low, the three-waste treatment is simple and feasible, the environment is friendly, the equipment used in the reaction process is simple, the raw materials are easy to obtain, and the method is suitable for industrial production The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide
The Article related to phenyltetrahydroisoquinoline preparation stereoselective hydrogenation phenyldihydroisoquinoline, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Recommanded Product: (S)-2-Hydroxy-N-methyl-2-phenylacetamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics