Huang, Wenhua; Dong, Guangping; Mijiti, Zumureti published an article in 2012, the title of the article was One-pot synthesis of 2,4,5-trisubstituted oxazoles from N-acyl amino acids by a combination of cyclodehydration with N,N’-diisopropylcarbodiimide and Wittig olefination.Quality Control of 2-(4-Methylbenzamido)acetic acid And the article contains the following content:
By a combination of cyclodehydration of N-acyl amino acids with N,N’-diisopropylcarbodiimide (DIC) and non-classical Wittig olefination of the resultant 5(4H)-oxazolones with Ph3P=CHCN and Ph3P=CHCOOEt, 5-oxazoleacetonitriles and 5-oxazoleacetates were synthesized in one-pot in 41-85% and 57-70% yields, resp. E.g., reaction of 4-MeC6H4CONHCH2CO2H with Ph3P:CHCN in presence of DIC gave 85% 5-oxazoleacetonitrile (I). The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Quality Control of 2-(4-Methylbenzamido)acetic acid
The Article related to acyl amino acid cyclodehydration wittig olefination, oxazoleacetonitrile preparation, oxazoleacetate preparation, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Quality Control of 2-(4-Methylbenzamido)acetic acid
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics