On August 14, 2014, Haq, Nadia; Niu, Deqiang; Petter, Russell C.; Qiao, Lixin; Singh, Juswinder; Zhu, Zhendong published a patent.Quality Control of N-(3-Aminophenyl)acrylamide The title of the patent was Pyrimidine derivatives as ERK inhibitors and their preparation. And the patent contained the following:
The invention provides compounds of formula I, compositions thereof, and methods of using the same. Compounds of formula I wherein A is (un)substituted Ph, 3- to 8-membered (un)saturated monocyclic ring, 4- to 7-membered monocyclic heterocyclic ring, etc.; B is (un)substituted Ph, (un)substituted (un)saturated 3- to 7-membered carbocyclic ring, 5- to 6-membered monocyclic heteroaryl, absent, etc.; m and p are independently 0 – 4; R1 is a warhead group, wherein R1 is attached to an atom adjacent to where W is attached; each R2 is H, (un)substituted C1-6 aliphatic, halo and OH and derivatives; each R3 is H, halo, OH and derivatives, SH and derivatives, CN, etc.; R4 is H, (un)substituted C1-6 aliphatic, halo, haloalkyl, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their ERK inhibitor activity (some data given). The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Quality Control of N-(3-Aminophenyl)acrylamide
The Article related to pyrimidine preparation erk inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Quality Control of N-(3-Aminophenyl)acrylamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics