On April 6, 2016, Fu, Kaiyong; Li, Hua; Zhang, Changjiang published a patent.Category: amides-buliding-blocks The title of the patent was Process for preparation of tyrosine kinase inhibitor Rociletinib. And the patent contained the following:
The invention relates to a method for preparing tyrosine kinase inhibitor Rociletinib, namely N-[3-[[2-[[4-(4-acetyl-1-piperazinyl)-2-p-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-acrylamide, with a total yield of 60-65%. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Category: amides-buliding-blocks
The Article related to preparation tyrosine kinase inhibitor rociletinib, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Category: amides-buliding-blocks
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics