On June 19, 2014, Ahmed, Mahbub; Ashall-Kelly, Alexander; Gueritz, Louisa; McKenna, Jeffrey; McKenna, Joseph; Mutton, Simon; Parmar, Rakesh; Shepherd, Jon; Wright, Paul published a patent.Recommanded Product: 5455-98-1 The title of the patent was Azacycloalkanopyrrolopyrimidinedione derivatives as CFTR modulators and their preparation. And the patent contained the following:
The invention provides a compound of formula I or a pharmaceutically acceptable salt thereof;a nd its therapeutic uses. The invention further provides a combination of pharmacol. active agents and a pharmaceutical composition Compounds of formula I wherein A is (CHR4)n; R1 is (un)substituted Ph, (un)substituted C4-7 cycloalkenyl and (un)substituted 5- to 6- membered heteroaryl; R2 is (un)substituted C1-6 alkyl, (un)substituted C3-7 cycloalkyl, (un)substituted C4-7 cycloalkenyl, etc.; R3 is Me and Et; when X is S, then Z is CHR4a and n is 1; when X is CHR4b, then Z is NR5 and N is 1 and 2; when Z is CHR4b, then Z is CHR4a and n is 0, 1 and 2; when X is C=CH2, CF2 and C(CH3)2, then Z is CHR4a and n is 0 and 1; R4 is H, C1-4 alkyl,C1-4 haloalkyl, Ph, etc.; R4a is H, C1-4 alkyl, C1-4 hydroxyalkyl, etc.; R4b is H and Me; R5 is H and C1-4 alkyl, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by cyclization of 6-(2-mercaptoethyl)-1,3-dimethyl-5-phenyl-1,6-dihydropyrrolo[3,4-d]pyrimidine-2,4-dione with 5-methylfuran-2-carboxaldehyde. The invention compounds were evaluated for their CFTR modulatory activity (some data given). The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Recommanded Product: 5455-98-1
The Article related to azacycloalkanopyrrolopyrimidinedione preparation cftr modulator, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: 5455-98-1
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics