On April 5, 2017, Zhang, Yinsheng; Gao, Yong; Wang, Qinglin; Wang, Zhao published a patent.Application of 16230-24-3 The title of the patent was Preparation of deuterated diphenylamino pyrimidine compounds for treating cancer. And the patent contained the following:
The title compound I [wherein R1-R7 and R10-R26 = independently H or D; with the proviso that at least one of them is D; R8 = trifluoromethyl; R9 = H; with exclusions] or pharmaceutically acceptable salts thereof were prepared for treating EGFR related disease, such as cancer. For example, II was prepared in a multi-step synthesis. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Application of 16230-24-3
The Article related to preparation deuteration diphenylaminopyrimidine treatment proliferation human, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application of 16230-24-3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics