Zhang, Feng-Hua; Wang, Chen; Xie, Jian-Hua; Zhou, Qi-Lin published an article in 2019, the title of the article was Synthesis of Tridentate Chiral Spiro Aminophosphine-Oxazoline Ligands and Application to Asymmetric Hydrogenation of α-Keto Amides.Category: amides-buliding-blocks And the article contains the following content:
A new type of tridentate chiral spiro aminophosphine-oxazoline ligands (SpiroOAP) were synthesized through four steps. The SpiroOAP ligands are highly efficient for the asym. hydrogenation of α-keto amides, providing a variety of synthetically useful α-hydroxy amides with excellent enantioselectivity (up to 98% ee) and turnover numbers (up to 10,000). The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).Category: amides-buliding-blocks
The Article related to chiral spiro aminophosphine oxazoline ligand preparation, keto amide aminophosphine oxazoline iridium catalyst enantioselective hydrogenation, hydroxy amide preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Alcohols and Thiols and other aspects.Category: amides-buliding-blocks
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics