On March 8, 2016, Xu, Yong published a patent.Synthetic Route of 16230-24-3 The title of the patent was Synthesis of N-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide. And the patent contained the following:
A method for preparing BTK inhibitor CC-292 of formula I, comprising: (1) reacting 4-(2-methoxyethoxy)aniline with cyanamide to obtain a compound of formula II; (2) reacting compound of formula II with di-Et 2-fluoromalonate to obtain a compound of formula III; (3)reacting III with trifluoromethanesulfonic anhydride to obtain a compound of formula IV; and (4) reacting IV with a compound of formula V to obtain I. Compound I can be used in therapy. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Synthetic Route of 16230-24-3
The Article related to diarylamino fluoropyrimidine derivative preparation btk inhibitor disease therapy, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Synthetic Route of 16230-24-3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics