On October 22, 2019, Xiang, Hua; Teng, Yu; Zou, Yumei; Lin, Xin; Wang, Xuening; Shen, Hongtao; Cheng, Yu; Ha, Si; Tong, Chao; Wang, Han published a patent.Quality Control of N-(3-Aminophenyl)acrylamide The title of the patent was Preparation of benzopyrimidine compounds useful as Btk or PI3K kinase inhibitors for the treatment of cancer. And the patent contained the following:
The invention relates to benzopyrimidine compounds of formula I and II, method for their preparation and their use as Btk or PI3K kinase inhibitors for the treatment of cancer. Compounds of formula I and II, wherein ring A is (hetero)aryl; R2 is H, C1-3alkyl, C1-3alkoxy, halo, etc.l R3 is H and Me; X is C, O and N; R3 is R4CONH; R4 is C1-4alkyl, C2-4alkeny and C2-4alkynyl; A is (CH2)2-4, and their pharmaceutically acceptable salts, are claimed. Example compound III was prepared via a multistep procedure (procedure given). The above compounds can be used for preparing Btk or PI3K kinase inhibitors to treat or prevent diseases related to protein kinase activity, including tumors, such as leukemias and lymphomas. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Quality Control of N-(3-Aminophenyl)acrylamide
The Article related to benzopyrimidine preparation btk pi3k kinase inhibitor treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Quality Control of N-(3-Aminophenyl)acrylamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics