On December 3, 2021, Wu, Xiaoyun; Li, Qinlan; Guo, Qian; Wan, Shanhe; Li, Zhonghuang; Zhang, Jiajie published a patent.Formula: C9H10N2O The title of the patent was Preparation of dioxopiperidinyl-isoindolyl-alkylamidophenylamino-pyrimidinylaminophenyl piperazinyl-oxopentanamide derivative and application thereof. And the patent contained the following:
The present invention relates to the preparation of dioxopiperidinyl-isoindolyl-alkylamidophenylamino-pyrimidinylaminophenyl piperazinyl-oxopentanamide derivative and application thereof. In particular, the dioxopiperidinyl-isoindolyl-alkylamidophenylamino-pyrimidinylaminophenyl piperazinyl-oxopentanamide derivative I (wherein, L contains at least one of an alkyl group, a carbonyl group, an ether bond or an amine group) were prepared The inventive compound can be used as an EFGR inhibitor, has strong inhibitory activity against the cell line H1975 with high expression of EGFRL858R/T790M, and can effectively inhibit the growth of lung cancer cells, which can be used for preparing drugs for treating, preventing, delaying, assisting in treating or treating diseases related to EGFR activity and drugs for treating tumor diseases. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Formula: C9H10N2O
The Article related to dioxopiperidinyl isoindolyl alkylamidophenylamino piperazinyl oxopentaneamide preparation efgr inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Formula: C9H10N2O
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics