On March 31, 2019, Spranitz, Peter; Soregi, Petra; Botlik, Bence Bela; Berta, Mate; Soos, Tibor published an article.Name: N,N-Diethylacetamide The title of the article was Organocatalytic Desymmetrisation of Fittig’s Lactones: Deuterium as a Reporter Tag for Hidden Racemisation. And the article contained the following:
Highly enantioselective desymmetrisation of Fittig’s lactones with alcs. was promoted by bifunctional cinchona squaramides to yield corresponding glutaric acid derivatives I [R = Me, cyclohexyl, Ph, etc.]. The reactions were carried out with monodeuterated methanol to detect possible hidden racemization of the stereogenic center. Current evidence suggested that racemization was not a relevant process for most substrates, partial erosion of enantioselectivity was only detected with ortho-substituted aryl derivates. The resultant glutaric acid derivatives possess a scaffold that was common in natural products and the compounds were also useful chiral building blocks for further synthetic endeavours. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Name: N,N-Diethylacetamide
The Article related to glutaric acid derivative enantioselective preparation, bicyclic fittig lactone organocatalytic desymmetrisation, Aliphatic Compounds: Esters, Linear Anhydrides, Acyl Peroxides, and Acyl Halides and other aspects.Name: N,N-Diethylacetamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics