Sanad, Sherif M. H.; Ahmed, Ahmed A. M.; Mekky, Ahmed E. M. published an article in 2020, the title of the article was Efficient synthesis and molecular docking of novel antibacterial pyrimidines and their related fused heterocyclic derivatives.Product Details of 79-07-2 And the article contains the following content:
3-(Benzo[d][1,3]dioxol-5-yl)-1-(thiophen-2-yl)prop-2-en-1-one (chalcone) reacted with thiourea and 6-amino-2-thioxo-2,3-dihydropyrimidin-4(1H)-one to give the corresponding 3,4-dihydro-1H-pyrimidine-2-thione and 2-thioxo-1H-pyrido[2,3-d]pyrimidin-4-one. Then, these compounds reacted with the appropriate hydrazonyl chlorides 4-R1C6H4NHN=C(Cl)R [R = C(O)Me, CO2Et; R1 = H, Me] in dioxane in presence of triethylamine to afford corresponding 1,5-dihydro-[1,2,4]triazolo[4,3-a]pyrimidines I [R = C(O)Me, CO2Et; R1 = H, Me] and their related fused pyridines II. Moreover, chalcone was cyclocondensed with 2-cyanothioacetamide to give corresponding 2-thioxo-1H-pyridine-3-carbonitrile, which was used as key synthon to synthesize fused heterocyclic compounds III [R2 = C(O)NH2, R3 = NH2; R2R3 = C(O)NHC(S)NH, C(O)NHC(O)NH, C(O)NHCH=N, C(O)NHC(Me)=N, C(O)NHC(SMe)=N]. The compound III [R2R3 = C(O)NHC(SMe)=N] reacted with appropriate hydrazonyl chlorides in dioxane in presence of triethylamine to yield corresponding pyrido[3′,2′:4,5]thieno[3,2-d][1,2,4]triazolo[4,3-a]pyrimidines IV [R = C(O)Me, CO2Et; R1 = H, Me]. Study of the in vitro antimicrobial activities of newly synthesized pyrimidines against different pathogenic bacterial and fungal strains were performed. The compound III [R2R3 = C(O)NHCH=N] showed the highest inhibitory activity against all bacteria with MIC values of 3.9, 7.81, 7.81, and 15.62μg/mL, resp., against Escherichia coli, Klebsiella pneumonia, Staphylococcus aureus and Streptococcus mutans, resp., as compared to reference drugs. Mol. docking was studied to predict the optimized conformation of pyrimidines as active ligands against Escherichia coli alk. phosphatase. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Product Details of 79-07-2
The Article related to pyrimidine preparation antibacterial antifungal docking pharmacokinetic cytotoxicity human, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Product Details of 79-07-2
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