Matsuura, Akihisa; Ano, Yusuke; Chatani, Naoto published an article in 2022, the title of the article was Nucleophilic aromatic substitution of non-activated aryl fluorides with aliphatic amides.Related Products of 685-91-6 And the article contains the following content:
Nucleophilic aromatic substitution (SNAr) reactions of non-activated aryl fluorides RF [R = (4-biphenyl), [4-(pyridin-2-yl)phenyl], naphthalen-1-yl, pyridin-3-yl, etc.] with amide enolates e.g., 1-methylpyrrolidin-2-one are reported. The reaction proceeds under relatively mild reaction conditions. Lactams also participate in the reaction to give 2-arylated lactams e.g., I. DFT calculations suggest that the reaction proceeds through a concerted SNAr pathway. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Related Products of 685-91-6
The Article related to amide preparation, aliphatic amide aryl fluoride nucleophilic aromatic substitution reaction, Aliphatic Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Related Products of 685-91-6
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics