On May 31, 2017, Ma, Xiaodong; Zhao, Dan; Wang, Luhong; Qu, Menghua; Huang, Shanshan; Wang, Changyuan; Shu, Xiaohong; Liu, Kexin published a patent.Computed Properties of 16230-24-3 The title of the patent was Sulfoamido pyrimidine compound as Bruton tyrosine kinase inhibitor and its preparation. And the patent contained the following:
The invention relates to sulfoamido pyrimidine compound of formula I as Bruton tyrosine kinase inhibitor and its preparation Compounds I, wherein R1 is Cl, F, nitro or trifluoromethyl; R2 is H, Me, methoxy or Cl; X is NH or O; R3 is Me, methoxy, or F; their pharmaceutically acceptable salts, are claimed. The inventive compound can inhibit Bruton tyrosine kinase, so as to treat tumors, especially Burkitts lymphoma, disseminated large B cell lymphoma, follicular lymphoma or chronic lymphocytic leukemia. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Computed Properties of 16230-24-3
The Article related to sulfoamido pyrimidine preparation bruton tyrosine kinase inhibitor treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Computed Properties of 16230-24-3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics