On February 1, 2020, Khalil, Nadia A.; Ahmed, Eman M.; Zaher, Ashraf F.; El-Zoghbi, Mona S.; Sobh, Eman A. published an article.Recommanded Product: 2-Chloroacetamide The title of the article was Synthesis of certain benzothieno[3,2-d]pyrimidine derivatives as a selective SIRT2 inhibitors. And the article contained the following:
A series of new benzothieno[3,2-d]pyrimidine derivatives were designed and synthesized. The National Cancer Institute (NCI, USA) evaluated all synthesized compounds against 60 human tumor cell lines. Most of the compounds showed good cytotoxicity against MCF-7 breast cancer cell line and UO-31 renal cancer cell line (growth inhibitory range: 17.88%-68.65%). IC50 of twelve most active compounds was determined against MCF-7 and UO-31 cell lines. IC50 against SIRT2 enzyme was evaluated for the most active compounds to explore the mechanism of antiproliferative activity. The best activity was displayed by compound I (IC50 = 2.10μg/mL), which is 6.6 more potent than cambinol as a reference Moreover, compound I displayed high selectivity against SIRT1 and SIRT2 over SIRT3 in the selectivity studies and displayed twice activity of cambinol in hyperacetylation of α-tubulin protein with IC50 = 32.05μg/mL. Mol. docking study of the synthesized compounds into SIRT2 active site was performed to rationalize the remarkable SIRT2 inhibitory activity. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Recommanded Product: 2-Chloroacetamide
The Article related to benzothienopyrimidine preparation antitumor sirutin inhibition mol docking sar, benzothieno[3,2-d]pyrimidines, cytotoxic activity, sirt2 inhibitors, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: 2-Chloroacetamide
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