On July 19, 1995, Hashiguchi, Shohei; Fujii, Akio; Takehara, Jun; Ikariya, Takao; Noyori, Ryoji published an article.Safety of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide The title of the article was Asymmetric Transfer Hydrogenation of Aromatic Ketones Catalyzed by Chiral Ruthenium(II) Complexes. And the article contained the following:
A chiral Ru(II) complex, prepared from [RuCl2(η6-mesitylene)]2 and (1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine, effects a highly enantioselective transfer hydrogenation of various aromatic alkyl ketones by iso-PrOH. The reduction of acetophenone in a 0.1M solution of iso-PrOH containing the Ru catalyst (substrate/catalyst (S/C) mole ratio = 200) and KOH (5 equiv to Ru atom) proceeds at room temperature to give (S)-1-phenylethanol in 97% ee and 95% yield. The enantioselectivity is slightly lowered as the reaction proceeds owing to the reversibility of the transfer hydrogenation. In a similar manner, a range of simple aromatic ketones (S/C = 200-500) are convertible to secondary alcs. with high enantiomeric purity. A relevant catalyst precursor was obtained by reacting [RuCl2(η6-benzene)]2 and (1S,2S)-N-trifluoromethanesulfonyl-1,2-diphenylethylenediamine in a 1:4 mol ratio in iso-PrOH. The mol. structure was determined by single-crystal x-ray anal. The experimental process involved the reaction of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide(cas: 167316-28-1).Safety of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide
The Article related to crystal structure ruthenium benzene sulfonylethylenediamine complex, ruthenium sulfonylethylenediamine transfer hydrogenation catalyst ketone, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Safety of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide
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