Month: October 2022

On May 5, 2006, Marko, Istvan; De Paolis, Michael; Mignani, Gerard published a patent.Computed Properties of 167316-28-1 The title of the patent was Use of an aromatic carboxylic acid in an asymmetric catalysis reaction, particularly Aldol condensation, in combination with pyrrolidine-containing chiral derivatives of diamines, amino alcohols, carbonyls, and monosulfonyl compounds. And the patent contained the following:

The invention is related to the use of strong aromatic carboxylic acids of formula I [B = aromatic carbocycle; L = alkyl(en)yl; n = number of R substituents, especially 1-2; each R = independently various substituents on ring B, with at least 1 substituent representing an electron attracting group] in combination with pyrrolidine-containing chiral catalysts such as derivatives of diamines, amino alcs., carbonyls, monosulfonyl compounds, in asym. catalysis, particularly asym. aldolization or ketolization. Thus, 2-nitrobenzoic acid in combination with 2-pyrrolidinamide derivative II was used in an aldolization reaction of 4-nitrobenzaldehyde in CH3CN-H2O-acetone. The experimental process involved the reaction of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide(cas: 167316-28-1).Computed Properties of 167316-28-1

The Article related to asym aldolization aryl carboxylic acid, aldol preparation asym catalysis, chiral catalyst asym aldol condensation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ketones and Derivatives, Including Quinones and Sulfur Analogs and other aspects.Computed Properties of 167316-28-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 28, 1982, Plakidin, V. L.; Vostrova, V. N. published an article.Synthetic Route of 97-09-6 The title of the article was Reaction of 2,4-disubstituted chlorobenzenes with 3-alkylamino and 3-dialkylaminopropionitriles. And the article contained the following:

Reaction of I (R, R1 = H, NO2; NO2, NO2; NO2, Cl; NO2, SO2Me; NO2, SO2NH2; NO2, SO2NMe2; CN, NO2) with R22NCH2CH2CN (R2 = Me, Et) at 65-170° gave (via the quaternary salt) II (13 compounds), and with R2NHCH2CH2CN (R2 = Me, Et) at 20-130° gave III (11 compounds). At ∼130° cleavage of the cyanomethyl group from III was observed The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Synthetic Route of 97-09-6

The Article related to substituted chlorobenzene amino nitrile, aniline derivative, benzenamine derivative, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amines, Amine Oxides, Imines, and Quaternary Ammonium Compounds and other aspects.Synthetic Route of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 2, 2002, Bhattacharya, Gautam; Salem, Manar M.; Werbovetz, Karl A. published an article.Formula: C6H5ClN2O4S The title of the article was Antileishmanial dinitroaniline sulfonamides with activity against parasite tubulin. And the article contained the following:

Novel dinitroaniline sulfonamides based on the herbicide oryzalin were synthesized and evaluated for activity against the parasitic protozoan Leishmania donovani and against leishmanial tubulin, the putative antiparasitic target of oryzalin. A subset of these compounds possess more activity against both Leishmania and the target protein in vitro. Compound I displays improved potency against leishmanial tubulin and is 13.4-fold more active against L. donovani axenic amastigotes than oryzalin. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Formula: C6H5ClN2O4S

The Article related to dinitroaniline sulfonamide preparation, antiparasitic leishmanial tubulin polymerization inhibiting aniline dinitro sulfonamide derivative, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amines, Amine Oxides, Imines, and Quaternary Ammonium Compounds and other aspects.Formula: C6H5ClN2O4S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 30, 2009, Shyamala, M.; Arulanantham, A. published an article.Category: amides-buliding-blocks The title of the article was Aegle marmelos as effective corrosion pickling inhibitor on mild steel in hydrochloric acid. And the article contained the following:

In this study, the corrosion inhibition effect of aqueous extract of Aegle marmelos in 1N hydrochloric acid has been investigated by weight loss, gasometric, potentiodynamic polarization and impedance methods. The Aegle marmelos was found to be effective corrosion pickling inhibitor. The effect of immersion time revealed that the extracts of Aegle marmelos has maximum inhibition efficiency of 97.5 % in presence of an optimum concentration of 8 % volume/volume of the extract at 3 h of immersion time. Similarly, in gasometric method, maximum efficiency was found to be 97.1 % in the same optimum concentration It was confirmed by potentiodynamic polarization and impedance methods, which showed a maximum efficiency of 97.5 % and 96.6 % resp. in the concentration 8 % in volume/volume Potentiodynamic polarization studies indicated that the plant extract behaves as mixed type inhibitor. The adsorption of Aegle marmelos follows Langmuir adsorption isotherm. The inhibition action is due to presence of the alkaloid aegeline in the leaves of Aegle marmelos. The protective film formed on the surface of the mild steel was confirmed by SEM studies. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Category: amides-buliding-blocks

The Article related to hydrochloric acid mild steel corrosion pickling inhibitor aegle marmelos, Ferrous Metals and Alloys: Corrosion (If The Primary Interest Is In The Metal), Erosion, Cavitation, Tribology, and Oxidation and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cohen, Irit; Mishra, Abhaya K.; Parvari, Galit; Edrei, Rachel; Dantus, Mauricio; Eichen, Yoav; Szpilman, Alex M. published an article in 2017, the title of the article was Sunlight assisted direct amide formation via a charge-transfer complex.Reference of N,N-Diethylacetamide And the article contains the following content:

We report on the use of charge-transfer complexes between amines and carbon tetrachloride, as a novel way to activate the amine for photochem. reactions. This principle is demonstrated in a mild, transition metal free, visible light assisted, dealkylative amide formation from feedstock carboxylic acids and amines. The low absorption coefficient of the complex allows deep light penetration and thus scale(coating process) up to a gram scale. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Reference of N,N-Diethylacetamide

The Article related to sunlight amide charge transfer complex, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Radiation Chemistry and Photochemistry and other aspects.Reference of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Blanco-Lomas, Marina; Funes-Ardoiz, Ignacio; Campos, Pedro J.; Sampedro, Diego published an article in 2013, the title of the article was Oxazolone-Based Photoswitches: Synthesis and Properties.SDS of cas: 27115-50-0 And the article contains the following content:

The synthesis, photophysics and photochem. of a family of mol. switches inspired by the green fluorescent protein (GFP) chromophore is presented. These compounds can be synthesized in one step and good yields, their photophys. properties may be tuned by the substituents, solvent and wavelength of irradiation, and they show very efficient and fast photoisomerization. Furthermore, their high thermal stability and limited photodecomposition could allow these switches to be used in a range of applications. Finally, oxazolone photoswitches may be activated by the use of light and deactivated by either heat or light of a different wavelength. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).SDS of cas: 27115-50-0

The Article related to photophysics photochem oxazolone based photoswitch, mol switch oxazolone derivative photoisomerization, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Radiation Chemistry and Photochemistry and other aspects.SDS of cas: 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Peiyuan; Naduthambi, Devan; Mosley, Ralph T.; Niu, Congrong; Furman, Phillip A.; Otto, Michael J.; Sofia, Michael J. published an article in 2011, the title of the article was Phenylpropenamide derivatives: Anti-hepatitis B virus activity of the Z isomer, SAR and the search for novel analogs.Electric Literature of 27115-50-0 And the article contains the following content:

Phenylpropenamides have been reported to be a class of non-nucleoside inhibitors of the hepatitis B virus (HBV). This class of compounds was explored with the objective of developing potent anti-HBV agents, with a novel mechanism of action, that could be combined with nucleos(t)ide analogs currently used to treat HBV infection. To accomplish this objective a series of substituted arylpropenamides I (X = Br, Cl; R1 = Ph, 2-MeOC6H4, 1,3-dioxolan-4-yl, 2-FC6H4, 4-MeC6H4; R2 = Ph, 4-O2NC6H4, 4-MeO2SC6H4, etc.; R3R4N = 1-piperidinyl, 4-morpholinyl, 4-methyl-1-piperazinyl, etc.) was prepared and the E and Z geometrical isomers were separated The structural identity of each of the E and Z isomers of I (X = Cl; R1 = R2 = Ph; R3R4N = 1-piperidinyl) was determined by single crystal X-ray crystallog. Contrary to previous reports, the activity of this class of mols. resides in the Z isomer. Further structure-activity relationship studies around the active Z isomer identified compounds that displayed potent antiviral activity against HBV with EC90 value of approx. 0.5 μM in vitro. Attempts to develop ring constrained analogs did not lead to active HBV inhibitors. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Electric Literature of 27115-50-0

The Article related to propenamide aryl aroylamino preparation antiviral hepatitis, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Electric Literature of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Azizi, Kobra; Madsen, Robert published an article in 2020, the title of the article was Radical condensation between benzylic alcohols and acetamides to form 3-arylpropanamides.Electric Literature of 685-91-6 And the article contains the following content:

A new radical condensation reaction was developed where benzylic alcs. and acetamides were coupled to generate 3-arylpropanamides ArCH2CH2C(O)NR1R2 [Ar = Ph, 4-ClC6H4, 1-naphthyl, etc.; R1 = R2 = Me, Et; R1 = H; R2 = Me; R1R2 = (CH2)5, (H2C)2O(CH2)2] with water as the only byproduct. The transformation was performed with potassium tert-butoxide as the only additive and gave a variety of 3-arylpropanamides ArCH2CH2C(O)NR1R2 in good yields. The mechanism was investigated exptl. with labeled substrates, trapping experiments and spectroscopic measurements. The findings indicated a radical pathway where potassium tert-butoxide was believed to serve a dual role as both base and radical initiator. The radical anion of the benzylic alc. was proposed as the key intermediate, which undergoes coupling with the enolate of the amide to form the new C-C bond. Subsequent elimination to the corresponding cinnamamide and olefin reduction then afforded the 3-arylpropanamides ArCH2CH2C(O)NR1R2. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Electric Literature of 685-91-6

The Article related to arylpropanamide preparation, benzylic alc acetamid condensation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Electric Literature of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 3, 2019, Bi, Yingzhi; Dorsey, Bruce D.; Fan, Yi; Moore, Christopher Brooks; Nguyen, Duyan published a patent.Product Details of 5455-98-1 The title of the patent was Preparation of substituted 1,1′-biphenyl compounds and analogues thereof, and methods for using them for treatment of HBV and HDV infections. And the patent contained the following:

The invention is related to the preparation of compounds I [X1 = CH, N; X2 = R2a = OCH2**, CH2O**, CONH**, NHCO**, wherein the bond marked with ** is to the Ph ring carbon marked with *; R1a, R1b = independently H, alkyl, alkoxy, CN, halo, haloalkyl; R1c = H, alkyl, OH, alkoxy optionally substituted; R2a = alkyl, alkoxy, (CH2)1-3(optionally substituted phenyl), etc.; R3a = CHO, COOH and derivatives, CONH2 and derivatives, etc.; R4a = halo, CN, alkyl], including substituted 3,3′-bis(phenoxymethyl)-1,1′-biphenyl compounds and their analogs, their salts, solvates, geometric isomers, stereoisomers, tautomers or any mixtures thereof, and compositions comprising them, that can be used to treat or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient. Thus, II was prepared from (2-methyl-3-phenylphenyl)methanol using 2,4-dihydroxybenzaldehyde, 3-(bromomethyl)benzonitrile and ethane-1,2-diamine. II displayed an IC50 of 0.28 in a PD-L1 HTRF assay. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Product Details of 5455-98-1

The Article related to biphenyl analog preparation pd1 pdl1 inhibitor antiviral hbv hdv, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Product Details of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Barham, Joshua P.; Tamaoki, Souma; Egami, Hiromichi; Ohneda, Noriyuki; Okamoto, Tadashi; Odajima, Hiromichi; Hamashima, Yoshitaka published an article in 2018, the title of the article was C-Alkylation of N-alkylamides with styrenes in air and scale-up using a microwave flow reactor.Product Details of 685-91-6 And the article contains the following content:

C-Alkylation of N-alkylamides with styrenes is reported, proceeding in ambient air/moisture to give arylbutanamides and pharmaceutically-relevant scaffolds in excellent mass balance. Various amide and styrene derivatives were tolerated, rapidly affording mol. complexity in a single step; thus highlighting the future utility of this transformation in the synthetic chem. toolbox. Reaction scalability (up to 65 g h-1 product) was demonstrated using a microwave flow reactor, as the first example of a C-alkylation reaction using styrenes in continuous flow. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Product Details of 685-91-6

The Article related to arylbutanamide preparation microwave flow reactor, alkylamide styrene alkylation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Product Details of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics