Month: October 2022

On September 30, 2014, Swapna, M.; Basha, N. Mahaboob; Padmaja, A.; Padmavathi, V. published an article.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid The title of the article was Synthesis of amino derivatives of 3-(4-phenyl-1,2,3-triazolyl)benzamine. And the article contained the following:

A new class of amino derivatives of 3-(4-phenyl-1,2,3-triazolyl)benzamine were prepared using different electrophilic reagents under ultrasonication and microwave methodologies. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

The Article related to phenyltraizolyl benzeneamine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application In Synthesis of 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Vasin, V. S.; Koldaeva, T. Yu.; Perevalov, V. P. published an article in 2012, the title of the article was Synthesis of derivatives of 2-(2-hydroxyphenyl)-2H-benzotriazole-4-carboxylic acid containing sulfonamide group in phenyl moiety.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide And the article contains the following content:

The method of synthesis of I from 3,5-diamino-4-chlorobenzoic acid and N-phenylamide of 3-amino-4-hydroxybenzenesulfonic acid was developed. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

The Article related to hydroxyphenyl benzotriazolecarboxylic acid sulfonamide preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 31, 2020, Pokhodylo, N. T.; Savka, R. D.; Obushak, M. D. published an article.Product Details of 79-07-2 The title of the article was Synthesis of (1H-1,2,3-Triazol-1-yl)acetic Acid Derivatives. And the article contained the following:

A convenient synthetic approach to (1H-1,2,3-triazol-1-yl)acetic acid derivatives via the reaction of azidoacetamides with β-ketoesters and acetylacetone is proposed. Based on this strategy, 1,5-disubstituted 1,2,3-triazoles were prepared from available reagents under metal-free conditions. A one-pot protocol for the synthesis of (5-methyl-1H-1,2,3-triazol-1-yl)acetamides derived from N-substituted chloroacetamides is developed. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Product Details of 79-07-2

The Article related to triazolyl acetic acid preparation acetamide, azidoacetamide ketoester acetylacetone alk hydrolysis cyclocondensation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Product Details of 79-07-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 21, 2017, Mei, Congmin; Li, Xu; Liu, Lihuai; Cao, Changsheng; Pang, Guangsheng; Shi, Yanhui published an article.Related Products of 5455-98-1 The title of the article was Selectively synthesis of cyclic di- and trithiocarbonates by N-heterocyclic carbene/LiCl(Br) catalyzed addition of carbon disulfide to epoxides. And the article contained the following:

Carbon disulfide is an abundant, inexpensive and readily available material. One of the main challenges in the reaction of epoxides with CS2 is to control the chemoselectivity as a variety of compounds would be formed in the reaction. A simple and convenient method toward selectively synthesis of oxathiolane and trithiocarbonate from epoxides with CS2 catalyzed by NHC/LiCl(Br) under the neat conditions was developed. This catalytic system exhibits excellent activity and selectivity in cycloaddition reactions of carbon disulfide to terminal epoxides. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Related Products of 5455-98-1

The Article related to heterocyclic carbene catalyst carbon disulfide epoxide cycloaddition, dithiocarbonate preparation, trithiocarbonate preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Related Products of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Matsunami, Asuka; Kayaki, Yoshihito; Ikariya, Takao published an article in 2015, the title of the article was Enhanced Hydrogen Generation from Formic Acid by Half-Sandwich Iridium(III) Complexes with Metal/NH Bifunctionality: A Pronounced Switch from Transfer Hydrogenation.Reference of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide And the article contains the following content:

By switching the catalytic function from transfer hydrogenation based on the metal/NH bifunctionality, facile dehydrogenation of formic acid was achieved by amido- and hydrido(amine)-Ir complexes derived from N-triflyl-1,2-diphenylethylenediamine (TfDPEN) at ambient temperature even in the absence of base additives. Further acceleration was observed by the addition of water, leading to a maximum turnover frequency above 6000 h-1. A proton-relay mechanism guided by the protic amine ligand and water is postulated for effective protonation of metal hydrides. The experimental process involved the reaction of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide(cas: 167316-28-1).Reference of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide

The Article related to hydrogen storage material formic acid dehydrogenation catalyst iridium complex, cooperative effects, dehydrogenation, homogeneous catalysis, hydride ligands, iridium, Electrochemical, Radiational, and Thermal Energy Technology: Energy Handling, Transport, and Storage and other aspects.Reference of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 15, 1999, Park, Kyung Jae; Oh, In Hwan; Mun, Jae Jun; Jung, Shin Hae published a patent.Formula: C9H10N2O The title of the patent was Method for the preparation of polymeric pigment. And the patent contained the following:

A process for preparing an acrylic based polymer pigment polymerized with a pigment itself by polymerizing an acrylic/azo based pigment monomer with a vinyl monomer is provided, which has excellent coloring property and workability for general plastic and engineering plastic as substantial matrix resin. This process comprises the steps of: preparing raw material for synthesizing 3-nitroacrylanilide by using 3-nitroaniline and acryloyl chloride in acetone as a solvent and sodium hydroxide as a catalyst; reducing 3-nitroacrylanilide using iron/hydrochloric acid in 50% methanol as a solvent; preparing an acrylic/azo based color monomer by reacting 3-aminoacrylanilide with sodium nitrate and coupling with a coupler; and polymerizing the acrylic/azo based color monomer and Me methacrylate. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Formula: C9H10N2O

The Article related to acrylic azo polymer pigment preparation, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Other Dyes and Pigments and other aspects.Formula: C9H10N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 24, 2017, Chen, Wenteng; Liu, Xingyu; Shao, Jiaan; Chen, En; Yu, Yongping published a patent.Application of 16230-24-3 The title of the patent was Preparation of 2-aminooimidazole pyridine derivatives as antitumor agents. And the patent contained the following:

The invention provides 2-aminooimidazole pyridine derivatives and method for preparing them, therfore. Experiments prove that the derivative has obvious proliferation inhibition effect on tumor cells (human epidermal carcinoma cell strain A431 overexpressing wild type EGFR, and Gefitinib-resistant human lung adenocarcinoma cell strain H1975) related with activity of EGFR tyrosine kinase activity at mol. level, particularly has preferable inhibition on drug-resistant cell strain H1975, has weak inhibitory activity on human colon cancer cell strain SW620 low expressing EGFR, and can be applied to prepare corresponding tumor cell-resistant drugs. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Application of 16230-24-3

The Article related to aminooimidazole pyridine preparation antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Application of 16230-24-3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 13, 2012, Su, Wei-Guo; Deng, Wei; Ji, Jianguo published a patent.Application of 5455-98-1 The title of the patent was Preparation of pyridopyrazine derivatives for use as Syk inhibitors. And the patent contained the following:

Title compounds I [each R1 independently = H, halo, CN, OH, (un)substituted alkyl, etc.; R2 = NH2, OH, C(O)H, (un)substituted alkyl, etc.; R3 and R4 independently = H, (un)substituted alkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl; or together with the N to which they are attached form an (un)substituted monocyclic, fused bicyclic, or spirocyclic ring optionally containing 1-3 heteroatoms selected from n, o, or S], and their pharmaceutically acceptable salts, are prepared and disclosed as Syk inhibitors. Thus, e.g., II was prepared by a multistep procedure (preparation given). Select I were evaluated in Syk kinase assays, e.g., II demonstrated an IC50 value in the range of 0.001 to <0.1 μM. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application of 5455-98-1

The Article related to pyridopyrazine derivative preparation syk inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Application of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 10, 2015, Xu, Yong; Wang, Xuehai; Li, Li’e; Huang, Lu; Tian, Hua; Yang, Zhongwen; Xia, Qingfeng; Xiao, Qiang; Guo, Diliang; Tu, Ronghua; Yu, Yanping; Yu, Jing; Huang, Xiang; Fan, Zhaoze; He, Zhenyu; Zhang, Yi; Yang, Jing published a patent.Category: amides-buliding-blocks The title of the patent was Purine compounds as kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases. And the patent contained the following:

The invention provides purine compounds of formula I and their preparing method and application. The inventive compounds can serve as Bruton’s tyrosine kinase (BTK) inhibitors. Compound of formula I wherein X is (un)substituted Ph, (un)substituted 3- to 7-membered saturated or unsaturated carbon ring, (un)substituted 8- to 10-membered saturated or unsaturated bicyclic ring or aryl ring, etc.; R1 is -R, halo, -OR, -O(CH2)aOR, -CN, -NO2, -SO2R, -SO2N(R)2, -SOR, -C(O)R, -CO2R, -C(O)N(R)2, -NRC(O)R, -NRC(O)NR2, -NRSO2R or -N(R)2; R2 is -R, halo, -OR, -O(CH2)aOR, -CN, -NO2, -SO2R, -SO2N(R)2, -SOR, -C(O)R, -CO2R, -C(O)N(R)2, -NRC(O)R, -NRC(O)NR2, -NRSO2R or -N(R)2; R is H, (un)substituted C1-6 alkyl, (un)substituted Ph, (un)substituted 4- to 7-membered heterocycle having 1-2 heteroatoms, (un)substituted 5- to 6-membered monocyclic heteroaryl ring including 1-4 heteroatoms, and the heteroatoms are selected from N, O, and S; and their stereoisomers, tautomers, pharmaceutically active metabolites, pharmaceutically acceptable salts, hydrates, solvates, or prodrugs as kinase inhibitors in the treatment of diseases thereof, are claimed. Compound of formula I were prepared via condensation of 2-chloro-9H-purin-6-amine with 4-hydroxypiperidine; the resulting 2-chloro-9-(4-piperidinyl)-9H-purin-6-amine underwent acylation with acryloyl chloride to give to give 2-chloro-6-(acryloylamino)-9-(1-acryloylamino-4-piperidinyl)-9H-purine, which underwent condensation with amines to give I. All the invention compounds were evaluated for their BTK inhibitory activity. From the assay, it was determined that two of the tested compounds exhibited the IC50 value of 0.016 μM. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Category: amides-buliding-blocks

The Article related to purine preparation btk kinase inhibitor treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 8, 2014, Xu, Yong; Wang, Xuehai; Li, Lie; Huang, Lu; Tian, Hua; Yang, Zhongwen; Xia, Qingfeng; Xiao, Qiang; Guo, Diliang; Tu, Ronghua; Yu, Yanping; Yu, Jing; Huang, Xiang; Fan, Zhaoze; He, Zhenyu; Zhang, Yi; Yang, Jing published a patent.Name: N-(3-Aminophenyl)acrylamide The title of the patent was Purine compounds as kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases. And the patent contained the following:

The invention provides purine compounds of formula I and their preparing method and application. The inventive compounds can serve as Bruton’s tyrosine kinase (BTK) inhibitors. Compound of formula I wherein X is (un)substituted Ph, (un)substituted 3- to 7-membered saturated or unsaturated carbon ring, (un)substituted 8- to 10-membered saturated or unsaturated bicyclic ring or aryl ring, etc.; R1 is -R, halo, -OR, -O(CH2)aOR, -CN, -NO2, -SO2R, -SO2N(R)2, -SOR, -C(O)R, -CO2R, -C(O)N(R)2, -NRC(O)R, -NRC(O)NR2, -NRSO2R or -N(R)2; R2 is -R, halo, -OR, -O(CH2)aOR, -CN, -NO2, -SO2R, -SO2N(R)2, -SOR, -C(O)R, -CO2R, -C(O)N(R)2, -NRC(O)R, -NRC(O)NR2, -NRSO2R or -N(R)2; R is H, (un)substituted C1-6 alkyl, (un)substituted Ph, (un)substituted 4- to 7-membered heterocycle having 1-2 heteroatoms, (un)substituted 5- to 6-membered monocyclic heteroaryl ring including 1-4 heteroatoms, and the heteroatoms are selected from N, O, and S; and their stereoisomers, tautomers, pharmaceutically active metabolites, pharmaceutically acceptable salts, hydrates, solvates, or prodrugs as kinase inhibitors in the treatment of diseases thereof, are claimed. Compound of formula I were prepared via condensation of 2-chloro-9H-purin-6-amine with 4-hydroxypiperidine; the resulting 2-chloro-9-(4-piperidinyl)-9H-purin-6-amine underwent acylation with acryloyl chloride to give to give 2-chloro-6-(acryloylamino)-9-(1-acryloylamino-4-piperidinyl)-9H-purine, which underwent condensation with amines to give I. All the invention compounds were evaluated for their BTK inhibitory activity. From the assay, it was determined that two of the tested compounds exhibited the IC50 value of 0.016 μM. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Name: N-(3-Aminophenyl)acrylamide

The Article related to purine preparation btk kinase inhibitor treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Name: N-(3-Aminophenyl)acrylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics