Month: October 2022

On August 31, 2010, Pace, Vittorio; Hoyos, Pilar; Fernandez, Maria; Sinisterra, Jose V.; Alcantara, Andres R. published an article.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was 2-Methyltetrahydrofuran as a suitable green solvent for phthalimide functionalization promoted by supported KF. And the article contained the following:

An efficient chemoselective nitrogen functionalization of phthalimides by using KF-Alumina in 2-methyltetrahydrofuran, a solvent obtained from renewable sources, is described. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to methyltetrahydrofuran green solvent alkylation phthalimide supported potassium fluoride, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ielo, Laura; Miele, Margherita; Pillari, Veronica; Senatore, Raffaele; Mirabile, Salvatore; Gitto, Rosaria; Holzer, Wolfgang; Alcantara, Andres R.; Pace, Vittorio published an article in 2021, the title of the article was Taking advantage of lithium monohalocarbenoid intrinsic α-elimination in 2-MeTHF: controlled epoxide ring-opening en route to halohydrins.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione And the article contains the following content:

A straightforward preparation of different β-halohydrins RCR1(OH)CH2X [R = Ph, 4-ClC6H4, 1,3-dioxoisoindolin-2-yl, etc.; R1 = H, Me, CF3, Ph; X = Cl, Br, I] through boosted Kirmse’s elimination of the corresponding lithium monohalocarbenoids starting from epoxide. Crucial for the development of the method was the use of the eco-friendly solvent 2-MeTHF, which forces the degradation of the incipient monohalolithium, due to the very limited stabilizing effect of this solvent on the chem. integrity of the carbenoid. The uniformly high-yield, the full preservation of the embodied stereochem. information and the high regiocontrol – deduced by selectively preparing variously decorated motifs further document the potential of this operationally simpleand intuitive methodol. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to halohydrin green preparation, epoxide lithium monohalocarbenoid ring opening elimination, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 15, 2022, Yu, Yao; Wang, Yang; Li, Bo; Tan, Yuqiang; Zhao, Huan; Li, Zheyu; Zhang, Chunran; Ma, Wenbo published an article.Recommanded Product: 1,3-Diphenylurea The title of the article was Ruthenium-Catalyzed Vinylene Carbonate Annulation by C-H/N-H Functionalizations: Step-Economical Access to Indoles. And the article contained the following:

A convenient and effective method of ruthenium-catalyzed C-H/N-H annulations using vinylene carbonate as oxidizing acetylene surrogate has been disclosed. This method is scalable and compatible with a wide range of functional groups, providing a step-economical access to indoles I (R = H, 5-Me, 7-Ph, 6-Br, etc.) and preliminary mechanistic studies provided support for a reversible, acetate-assisted C-H ruthenation, along with a subsequent olefin insertion. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Recommanded Product: 1,3-Diphenylurea

The Article related to indole preparation, anilide dioxolone ruthenium catalyst heterocyclization carbon bond activation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Shyamsundar, M.; Shamshuddin, S. Z. Mohamed published an article in 2019, the title of the article was Mo (VI)/ZrO2 coated on honeycomb monolith as solid acid green catalyst for the acetylation of substituted alcohols and amines under solvent free conditions.Synthetic Route of 685-91-6 And the article contains the following content:

Honeycomb (HC) monolith coated with solid acids such as Mo (VI)/ZrO2 (MZ) with different Mo loadings (2, 6 and 10%) have been prepared by wet impregnation method and characterized by NH3 -TPD, BET surface area, PXRD, ICPOES, SEM, TEM and EDAX techniques. These catalysts have been used as for the synthesis of O and N-acetylation reactions by the condensation of various alcs. with acetic anhydride under solvent free conditions in shorter times (20 min) at moderate temperature (70°C). Especially, 6% Mo (VI)/ZrO2 catalysts are found to be highly acidic and also resulted in high yields of O and N acetylated products up to ~99%. This methodol. offers several advantages such as excellent yields, easy procedure, mild and environmentally benign conditions. MZ catalysts are found to be economical, efficient and highly active, recyclable and reusable up to 6 reaction cycles without much loss of their activity. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Synthetic Route of 685-91-6

The Article related to molybdenum zirconia coated honeycomb monolith solid acid green catalyst, substituted alc acetylation, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Synthetic Route of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 1, 2014, Halimehjani, Azim Ziyaei; Hooshmand, Seyyed Emad; Shamiri, Elham Vali published an article.Formula: C11H9NO3 The title of the article was Synthesis of α-phthalimido-α’-dithiocarbamato propan-2-ols via a one-pot, three-component epoxide ring-opening in water. And the article contained the following:

Regioselective ring-opening of the N-(2,3-epoxypropyl)phthalimide with in situ prepared dithiocarbamic acid in water is reported for the synthesis of a new family of α-phthalimido-α’-dithiocarbamato propan-2-ols. The present method is simple, EtOAc is used for work-ups and affords excellent yield of products. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Formula: C11H9NO3

The Article related to phthalimido thiocarbamato propanol preparation, multicomponent phthalimido epoxide ring opening primary amine, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Formula: C11H9NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Le, Zhang-Gao; Zhong, Tao; Xie, Zong-Bo; Xu, Jian-Ping published an article in 2011, the title of the article was Solvent-free N-alkylation of phthalimide catalyzed by basic ionic liquids.SDS of cas: 5455-98-1 And the article contains the following content:

Solvent-free N-alkylation of phthalimide with alkyl halides catalyzed by basic ionic liquids is reported in this communication. With a comparative study, [Bmim]OH (1-butyl-3-methylimidazolium hydroxide) exhibited the highest catalytic activity among the selected basic ionic liquids, which afforded a convenient, efficient and general protocol for N-alkyl phthalimides exclusively. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).SDS of cas: 5455-98-1

The Article related to phthalimide n alkyl preparation solvent free condition, alkyl halide phthalimide n alkylation ionic liquid catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.SDS of cas: 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 25, 2020, Kulal, Nagendra; John, Crowny; Shanbhag, Ganapati V. published an article.Recommanded Product: 1,3-Diphenylurea The title of the article was Rational design of bifunctional catalyst from KF and ZnO combination on alumina for cyclic urea synthesis from CO2 and diamine. And the article contained the following:

This study is mainly focused on the design of stable, active and selective catalyst for direct synthesis of 2-imidazolidinone (cyclic urea) from ethylenediamine and CO2. Based on the rationale for the catalyst properties needed for this reaction, KF, ZnO and Al2O3 combination was selected to design the catalyst. ZnO/KF/Al2O3 catalyst was prepared by stepwise wet-impregnation followed by the removal of physisorbed KF from the surface. High product yield could be achieved by tuning acid-base sites by varying the composition and calcination temperature The catalysts were characterized by various techniques like XRD, N2-sorption, NH3-TPD, CO2-TPD, TEM, XPS and FT-IR measurements. It is shown that acidic and basic properties of the solvent can influence the activity and product selectivity for this reaction. Under optimized condition; 180°C, 10 bar and 10 weight% catalyst in batch mode, 96.3% conversion and 89.6% selectivity towards the 2-imidazolidinone were achieved. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Recommanded Product: 1,3-Diphenylurea

The Article related to bifunctional catalyst potassium fluoride zinc oxide alumina cyclic urea, carbon dioxide diamine cyclic urea catalyst, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Recommanded Product: 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 19, 2012, Pace, Vittorio; Holzer, Wolfgang published an article.Related Products of 5455-98-1 The title of the article was A straightforward and general access to α-phthalimido-α’-substituted propan-2-ones. And the article contained the following:

The regioselective ring opening of the com. available N-(2,3-epoxypropyl)phthalimide with different nucleophiles, to obtain the corresponding phthalimidopropan-2-ols (including a challenging fluorohydrin) followed by the Dess-Martin periodinane oxidation, constitutes a general and widely applicable protocol for the preparation of differently functionalized α-phthalimido-α’-substituted propan-2-ones I [R = Cl, Br, F, etc.]. The incorporation of the substituent in the α’ position takes place in an early stage of the process, thus furnishing a divergent and valuable approach. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Related Products of 5455-98-1

The Article related to regioselective ring opening epoxypropylphthalimide, phthalimidopropanol preparation dess martin oxidation, phthalimidopropanone preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Related Products of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 30, 2011, Suzdalev, K. F.; Den’kina, S. V. published an article.Recommanded Product: 2-(4-Methylbenzamido)acetic acid The title of the article was Synthesis of 1-(oxiran-2-ylmethyl)-1H-indole-3-carbaldehyde and its reaction with active methylene compounds. And the article contained the following:

Treatment of indole-3-carbaldehyde with epichlorohydrin gave 1-(oxiran-2-ylmethyl)-1H-indole-3-carbaldehyde, reaction of which with 1,3-dimethylbarbituric acid or malononitrile gave crotonic condensation products with retention of the oxirane ring. The structure of the reaction products with aroylglycines depends on the conditions. In acetic anhydride a simultaneous formation of an oxazolone ring and bisacylation of the oxirane fragment occurs; the use of Et chloroformate in the presence of triethylamine resulted in only the heterocyclization process. When treated with the cyclic amines (N-methylpiperazine or morpholine), opening of the oxazolone ring in the products occurs with formation of the corresponding amides. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Recommanded Product: 2-(4-Methylbenzamido)acetic acid

The Article related to oxiranylmethylindolecarbaldehyde preparation reaction active methylene compound, indolecarbaldehyde oxiranylmethyl preparation reaction active methylene compound, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 20, 2017, Aruri, Hariprasad; Singh, Umed; Kumar, Mukesh; Sharma, Sumit; Aithagani, Sravan Kumar; Gupta, Vivek K.; Mignani, Serge; Vishwakarma, Ram A.; Singh, Parvinder Pal published an article.Recommanded Product: 685-91-6 The title of the article was Metal-free Cross-Dehydrogenative Coupling of HN-azoles with α-C(sp3)-H Amides via C-H Activation and Its Mechanistic and Application Studies. And the article contained the following:

A metal-free one step coupling reaction between various N-azole rings and diverse α-C(sp3)-H containing amides has been developed under oxidative reaction conditions. Com. available tetrabutylammonium iodide (TBAI) in the presence of tert-Bu hydroperoxide (TBHP), under neat reaction conditions, efficiently catalyzed the coupling. Various azole types, such as 1H-benzotriazoles, 1H-1,2,3-triazoles, 1H-1,2,4-triazoles, 1H-tetrazoles, 1H-pyrazoles, and 1H-benzimidazoles, and α-C(sp3)-H containing amides, such as N,N-dimethylacetamide, N,N-dimethylbenzamide, N-methylacetamide, N,N-diethylacetamide, N-methylpyrrolidine, and pyrrolidin-2-one, were successfully employed for the coupling. A series of designed and controlled experiments were also performed in order to study the involvement of the different intermediates. Based on the evidence, a plausible mechanism is also proposed. These novel, simple, rapid, attractive, and straightforward transformations open the way of the construction of novel highly functionalized N-azoles via direct covalent N-H bond transformations onto N-C bonds. This approach allows to the synthesis of complex mols. requiring number of steps using classical synthetic ways. In addition, the range of α-C(sp3)-H containing amide substrates is virtually unlimited highlighting the potential value of this simple system for the construction of complex heterocyclic mols., such as fused azole derivatives The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Recommanded Product: 685-91-6

The Article related to dehydrogenative coupling azole amide, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Recommanded Product: 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics