Wang, Peiyuan; Naduthambi, Devan; Mosley, Ralph T.; Niu, Congrong; Furman, Phillip A.; Otto, Michael J.; Sofia, Michael J. published an article in 2011, the title of the article was Phenylpropenamide derivatives: Anti-hepatitis B virus activity of the Z isomer, SAR and the search for novel analogs.Electric Literature of 27115-50-0 And the article contains the following content:
Phenylpropenamides have been reported to be a class of non-nucleoside inhibitors of the hepatitis B virus (HBV). This class of compounds was explored with the objective of developing potent anti-HBV agents, with a novel mechanism of action, that could be combined with nucleos(t)ide analogs currently used to treat HBV infection. To accomplish this objective a series of substituted arylpropenamides I (X = Br, Cl; R1 = Ph, 2-MeOC6H4, 1,3-dioxolan-4-yl, 2-FC6H4, 4-MeC6H4; R2 = Ph, 4-O2NC6H4, 4-MeO2SC6H4, etc.; R3R4N = 1-piperidinyl, 4-morpholinyl, 4-methyl-1-piperazinyl, etc.) was prepared and the E and Z geometrical isomers were separated The structural identity of each of the E and Z isomers of I (X = Cl; R1 = R2 = Ph; R3R4N = 1-piperidinyl) was determined by single crystal X-ray crystallog. Contrary to previous reports, the activity of this class of mols. resides in the Z isomer. Further structure-activity relationship studies around the active Z isomer identified compounds that displayed potent antiviral activity against HBV with EC90 value of approx. 0.5 μM in vitro. Attempts to develop ring constrained analogs did not lead to active HBV inhibitors. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Electric Literature of 27115-50-0
The Article related to propenamide aryl aroylamino preparation antiviral hepatitis, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Electric Literature of 27115-50-0
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics