On December 13, 2012, Su, Wei-Guo; Deng, Wei; Ji, Jianguo published a patent.Application of 5455-98-1 The title of the patent was Preparation of pyridopyrazine derivatives for use as Syk inhibitors. And the patent contained the following:
Title compounds I [each R1 independently = H, halo, CN, OH, (un)substituted alkyl, etc.; R2 = NH2, OH, C(O)H, (un)substituted alkyl, etc.; R3 and R4 independently = H, (un)substituted alkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl; or together with the N to which they are attached form an (un)substituted monocyclic, fused bicyclic, or spirocyclic ring optionally containing 1-3 heteroatoms selected from n, o, or S], and their pharmaceutically acceptable salts, are prepared and disclosed as Syk inhibitors. Thus, e.g., II was prepared by a multistep procedure (preparation given). Select I were evaluated in Syk kinase assays, e.g., II demonstrated an IC50 value in the range of 0.001 to <0.1 μM. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application of 5455-98-1
The Article related to pyridopyrazine derivative preparation syk inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Application of 5455-98-1
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics