Somanathan, Ratnasamy; Aguilar, Hugo R.; Ventura, G. Rodriguez; Smith, Kevin M. published an article in 1983, the title of the article was Syntheses of natural hydroxyamides using trimethylsilyl cyanide.Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide And the article contains the following content:
Addition of Me3SiCN to p-anisaldehyde gave 64% p-MeOC6H4CH(CN)OSiMe3, which was reduced to give p-MeOC6H4CH(OH)CH2NH2 (I). Acylation of I with RCOCl gave 77-92% tembamide (I, R = Ph), aegeline (I, R = styryl), and I [R = 3-pyridyl, Me(CH2)7]. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide
The Article related to silyl cyanide synthetic reagent, hydroxyamide naturally occurring, amide hydroxy naturally occurring, tembamide aegeline, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics