Ielo, Laura; Miele, Margherita; Pillari, Veronica; Senatore, Raffaele; Mirabile, Salvatore; Gitto, Rosaria; Holzer, Wolfgang; Alcantara, Andres R.; Pace, Vittorio published an article in 2021, the title of the article was Taking advantage of lithium monohalocarbenoid intrinsic α-elimination in 2-MeTHF: controlled epoxide ring-opening en route to halohydrins.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione And the article contains the following content:
A straightforward preparation of different β-halohydrins RCR1(OH)CH2X [R = Ph, 4-ClC6H4, 1,3-dioxoisoindolin-2-yl, etc.; R1 = H, Me, CF3, Ph; X = Cl, Br, I] through boosted Kirmse’s elimination of the corresponding lithium monohalocarbenoids starting from epoxide. Crucial for the development of the method was the use of the eco-friendly solvent 2-MeTHF, which forces the degradation of the incipient monohalolithium, due to the very limited stabilizing effect of this solvent on the chem. integrity of the carbenoid. The uniformly high-yield, the full preservation of the embodied stereochem. information and the high regiocontrol – deduced by selectively preparing variously decorated motifs further document the potential of this operationally simpleand intuitive methodol. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione
The Article related to halohydrin green preparation, epoxide lithium monohalocarbenoid ring opening elimination, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione
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