On April 30, 2015, Huang, Min-yi; Xu, Wei; Huang, Jun-jun; Huang, Ya-jian; Yuan, Mu published an article.Formula: C11H9NO3 The title of the article was Synthesis, crystal structure and biological activity of N-(2-hydroxy-3-(4-(2-methoxyphenyl)-piperazin-1-yl)propyl)quinoxaline-2-methanamide. And the article contained the following:
The title compound N-(2-hydroxy-3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)-quinoxaline-2-methanamide (I, C23H27N5O3, Mr = 421.50) was synthesized via a four-step reaction and characterized by 1H NMR, 13C NMR, ESIMS and single-crystal X-ray diffraction. The crystal is of monoclinic, space group P21/n with a = 12.108(2), b = 12.639(3), c = 14.601(3) Å, β = 104.87(3)°, V = 2,159.6(8) Å3, Z = 4, Dc = 1.296 g/cm3, S = 1.023, μ = 0.088 mm-1, F(000) = 896, R = 0.0392 and wR = 0.0983 for 2,836 observed reflections with I>2σ (I). The single-crystal X-ray structural anal. reveals that I is stabilized by intramol. and intermol. hydrogen bonds together with π-π interactions. The bioassay showed that I exhibited high selective activity for α1A/D vs. α1B-adrenoceptors subtype. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Formula: C11H9NO3
The Article related to methoxyphenylpiperazinylpropyl quinoxalinecarboxamide preparation adrenoceptor antagonistic activity crystal mol structure, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Formula: C11H9NO3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics