On January 1, 2021, Gu, Xiaoke; Zhang, Yinpeng; Zou, Yueting; Li, Xin; Guan, Mingyu; Zhou, Qingqing; Qiu, Jingying published an article.Electric Literature of 27115-50-0 The title of the article was Synthesis and evaluation of new phenyl acrylamide derivatives as potent non-nucleoside anti-HBV agents. And the article contained the following:
As a continuation of our previous work, a series of new Ph acrylamide derivatives were designed and synthesized as non-nucleoside anti-HBV agents. Among them, compound I could potently inhibit HBV DNA replication in wild-type and lamivudine (3TC)/entecavir resistant HBV mutant strains with IC50 values of 0.19 and 0.18μM, resp. Notably, the selective index value of I was above 526, indicating the favorable safety profile. Interestingly, unlike nucleoside analog 3TC, I could significantly inhibit 3.5 kb pgRNA expression. Mol. docking study revealed that I could fit well into the dimer-dimer interface of HBV core protein by hydrophobic, π-π and H-bond interactions. Considering the potent anti-HBV activity, low toxicity and diverse anti-HBV mechanism from that of nucleoside anti-HBV agent 3TC, compound I might be a promising lead to develop novel non-nucleoside anti-HBV therapeutic agents, and warranted further investigation. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Electric Literature of 27115-50-0
The Article related to ph acrylamide preparation potent non nucleoside antihbv agent safety, anti-hbv agents, non-nucleoside, phenyl acrylamide derivatives, synthesis, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Electric Literature of 27115-50-0
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics