On September 2, 2002, Bhattacharya, Gautam; Salem, Manar M.; Werbovetz, Karl A. published an article.Formula: C6H5ClN2O4S The title of the article was Antileishmanial dinitroaniline sulfonamides with activity against parasite tubulin. And the article contained the following:
Novel dinitroaniline sulfonamides based on the herbicide oryzalin were synthesized and evaluated for activity against the parasitic protozoan Leishmania donovani and against leishmanial tubulin, the putative antiparasitic target of oryzalin. A subset of these compounds possess more activity against both Leishmania and the target protein in vitro. Compound I displays improved potency against leishmanial tubulin and is 13.4-fold more active against L. donovani axenic amastigotes than oryzalin. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Formula: C6H5ClN2O4S
The Article related to dinitroaniline sulfonamide preparation, antiparasitic leishmanial tubulin polymerization inhibiting aniline dinitro sulfonamide derivative, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amines, Amine Oxides, Imines, and Quaternary Ammonium Compounds and other aspects.Formula: C6H5ClN2O4S
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics